Our Researchers
Rima Rozen, PhD
Medical Genetics and Genomics AxisResearch Focus
Research is focused on the investigation of common genetic variants that increase risk for birth defects, vascular disease and cancer. These variants are involved in the metabolism of folic acid, an important vitamin which is required for prevention of the afore-mentioned disorders. The laboratory uses cell and molecular approaches, animal models and clinical research to understand the mechanisms by which genetic factors and nutrition influence these complex traits and to explore new avenues of intervention and treatment.
Keywords
Human genetics, metabolic diseases, cancer, folic acid, homocysteine
Selected Publications
Leclerc D, Rozen R. Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer. J Biol Chem 283(6): 3151-3160; 2007.
Related Links
Online version: Journal of Biological Chemistry
Mikael L, Genest Jr. J, Rozen R. Elevated homocysteine reduces Apolipoprotein A-1 expression in hyperhomocysteinemic mice and in males with coronary artery disease. Circulation Res 98: 564-571; 2006.
Knock E, Deng L, Wu Q, Leclerc D, Wang X-L, Rozen R. Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators Polo-Like Kinase 1 and Cell Division Cycle 25c. Cancer Research 66: 10349-10356; 2006.
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