Our Researchers
Richard Kremer, MD
Musculoskeletal Disorders AxisResearch Focus
Research areas include: 1) Vitamin D action in normal and cancer cells, 2) Effect of parathyroid hormone-related peptide (PTHrP) in tumor progression, 3) Therapeutic strategies in skeletal metastases, and 4) role and mechanism of action of vitamin D and growth factors in osteoporosis.
Keywords
Vitamin D, PTHrP, bone, cancer, osteoporosis, bone metastases
Selected Publications
Truong NY, deB Edwardes M, Papavasiliou V, Goltzman D, Kremer R. Parathyroid hormone related peptide and survival of patients with cancer and hypercalcemia. American Journal of Medicine 2003; 115:115-121.
El Abdaimi K, Dion N, PapavasiliouV, Cardinal PE, BinderupL, Goltzman D, Sainte Marie LG, Kremer R. The vitamin D analogue EB1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells. Cancer Research 2000; 60:4412-4418.
Solomon C, White JH, Kremer R. Mitogen-activated protein kinase inhibits 1,25- dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor α. Journal of Clinical Investigation 1999; 103:1729-1735.
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