Maya Saleh, PhD

Research Focus

Study of programmed cell death and inflammatory cytokine processing. Research revolves around understanding how signals to a cell are translated into decisions to live or die at the cellular level, and what impact that has on the organism, especially in relation to oncogenesis and immune diseases. Our laboratory makes use of a wide array of molecular biology, cell biology and genetics approaches to explore how the key players in cell death and cytokine maturation, the caspases, work to regulate cell suicide and bacterial clearance. Deregulation of their activity has been implicated in various diseases such as cancer, neurodegenerative diseases and sepsis.

Keywords

Apoptosis, caspases, cancer, inflammation, bacterial clearance, sepsis, polymorphisms in the human population, knockout/knockin mice, transgenic mice