Our Researchers
Jean-Pierre Routy
Infection and Immunity AxisResearch Focus
Dr. Routy’s objective is to better understand the immune correlate for the human immunodeficiency virus (HIV) control and to decipher the role of cytokines and growth hormones such as interleukin-2 (IL-2), IL-7 and keratinocyte growth factor (KGF) in T-cell reconstitution. He is also conducting clinical trials using cytokine and/or dendritic cell-based therapies along with specific vaccines in patients with HIV or suffering from hematological malignancies.
Keywords
T-cell recovery, HIV/AIDS, primary HIV infection, lymphoma, Kaposi sarcoma, viral resistance, cytokines, and flow cytometry
Selected Publications
Bestawros A, René M, Boulassel MR and Routy JP. HHV-8 linked to Kaposi’s sarcoma, Castleman’s disease and primary effusion lymphoma in a HIV-positive man. J Clin Virol (In press) 2008.
Mercier F, Boulassel MR, Yassine-Diab B, Tremblay C, Bernard NF, Sekaly RP, Routy JP. Persistence of HIV-1 antigenemia affects the expression of IL7Rα on central and effector memory CD4+ and CD8+ T cell subsets. J Clin and Exp. Immunol 152: 72-80; 2008.
vanGrevenynghe J, ProcopioFA , He1 Z, Chomont N , Riou1 C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, ShiY, Yassine-Diab B, Said E, Trautmann L, El Far M, Baldera RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP. Transcriptional factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection. Nat Med 14: 266-274; 2008.
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