Our Researchers
Gabriella Gobbi
Mental Illness and Addiction AxisResearch Focus
Research is focused in the pathophysiology of depression and anxiety,and in the discovery of new potential antidepressant drugs. Present research is focused on the implication of Substance P and NK1 receptor in the treatment of major depression and in the relationship between cannabis consumption and mood disorders. Techniques used in this lab are in vivo electrophysiology and in vivo behavioral pharmacology. Transgenic animals are also used as models of mood disorders.
Keywords
Depression, mood disorders, cannabis, marijuana, anxiety, serotonin, electrophysiology, antidepressant drugs, anti-anxiety drugs, psychiatry, addiction, psychopharmacology
Selected Publications
Gobbi G, Blier P. Effects of Neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs. Peptides 2005 (in press)
Santarelli L, Gobbi G, Debs PC, Sibille E, Blier P, Hen R, Heath M. Genetic and pharmacological disruption of NK1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proceeding of National Academy of Sciences of the USA 2001; 98:1912-1917.
Gobbi G, Lesch KP, Murphy DL, Blier P. Modifications of the serotoninergic system in mice lacking serotonin transporters. An in vivo electrophysiological study. The Journal of Pharmacology and Experimental Therapeutics 2001; 296: 987-995.
Contact