Our Researchers
David Goltzman
Musculoskeletal Disorders AxisResearch Focus
Research focuses on the hormonal regulation of calcium and skeletal homeostasis and the biology of the hormones, parathyroid hormone related peptide, parathyroid hormone, calcitonin and vitamin D. This is geared to understanding the interaction of cancer with the skeleton, identification of novel tumour markers and on mechanisms of development, diagnosis and treatment of osteoporosis, osteomalacia, and other metabolic bone diseases.
Keywords
parathyroid hormone(PTH), parathyroid hormone related peptide(PTHrP), vitamin D, calcium homeostasis, osteoporosis, renal osteodystrophy, rickets, genetic models of bone disease, molecular mechanisms of skeletal development
Selected Publications
Xiu Y, Karaplis A, Hendy GN, Goltzman D, Miao D. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distict and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Human Molecular Genetics 2005; 14: 1515-1528.
Panda DK, Miao D, Bolivar I, Li J, Huo R, Hendy GN, Goltzman D. Inactivation of the 25-hydroxyvitamin D-1 alpha-hydroxylase and vitamin D receptor demonstrates independent effects of calcium and vitamin D on skeletal and mineral homeostasis. Journal of Biological Chemistry 2004; 29: 16754-16766.
Miao D, He B, Karaplis AC, Goltzman D. Parathyroid hormone is essential for normal fetal bone formation. Journal of Clinical Investigation 2002; 109:1173-1182.
Contact
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